2-Amino-9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one(CAS: 7665-99-8)

The compound is a crystalline solid with a molecular weight of approximately 453.18 g/mol. It is slightly soluble in water and more soluble in polar solvents like ethanol and acetonitrile. Chemically, it is reactive towards nucleophiles, particularly amino groups and hydroxyl groups. It exhibits acidic and basic properties typical of purines and phosphorus-containing compounds.

This compound is typically synthesized via multistep organic synthesis routes using protected purine derivatives and phosphorus-containing intermediates. Key steps involve protection of functional groups, ring formation, and deprotection. Catalysts such as palladium(II) acetate and bases like cesium carbonate are often used. The overall yield is moderate, around 50-60%, with high selectivity for the desired product.

This compound is primarily used in pharmaceuticals for the development of novel therapeutics. It also finds applications in the synthesis of advanced materials, such as polymers and semiconductors, where its unique chemical structure is utilized. Additionally, it can be used in the fabrication of sensors due to its reactivity and specific functional groups.

When handling this compound, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure laboratory fume hoods are used during operations to minimize inhalation risk. Spills should be cleaned up with mild acids or bases, and the site should be well-ventilated. Always refer to the safety data sheet (SDS) for specific instructions and emergency procedures.