Compound Q&A
How is 2-Amino-9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one (CAS: 7665-99-8) typically synthesized?
Answer
![2-Amino-9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one](https://static.chemtradehub.com/structs/766/7665-99-8-ca62.webp "2-Amino-9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one")
This compound is typically synthesized via multistep organic synthesis routes using protected purine derivatives and phosphorus-containing intermediates. Key steps involve protection of functional groups, ring formation, and deprotection. Catalysts such as palladium(II) acetate and bases like cesium carbonate are often used. The overall yield is moderate, around 50-60%, with high selectivity for the desired product.
About
CAS No
7665-99-8
English Name
2-Amino-9-[(4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one
Molecular Formula
C10H12N5O7P
Molecular Weight
345.2080000000001 g/mol
SMILES
C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(O1)O
InChIKey
ZOOGRGPOEVQQDX-UUOKFMHZSA-N
Last Updated: 2025-10-10 13:51
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