(E)-Ethyl 2-(2-(2-bromophenyl)hydrazono)propanoate(CAS: 18474-55-0)

(E)-Ethyl 2-(2-(2-bromophenyl)hydrazono)propanoate is a crystalline solid with a molecular weight of approximately 357.04 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. The compound exhibits limited reactivity, primarily due to the bromine substituent, which affects its stability and reactivity in aqueous environments.

(E)-Ethyl 2-(2-(2-bromophenyl)hydrazono)propanoate is synthesized via a hydrazination reaction of ethyl malonate with 2-bromophenylhydrazine. The reaction typically occurs in the presence of a mild base like potassium carbonate and is performed at room temperature. The yield is generally between 70-80%, with high selectivity towards the E-isomer.

(E)-Ethyl 2-(2-(2-bromophenyl)hydrazono)propanoate is used in the pharmaceutical industry for the synthesis of certain anti-inflammatory and antiparasitic drugs. It is also explored in polymer production for its potential as a stabilizer. Additionally, it may be used in the development of sensors and as a reagent in analytical chemistry.

When handling (E)-Ethyl 2-(2-(2-bromophenyl)hydrazono)propanoate, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or in a fume hood. Spills should be cleaned up using appropriate absorbents, and the area should be ventilated thoroughly. Refer to the Safety Data Sheet (SDS) for detailed emergency response procedures and storage guidelines.