5-Iodo-1H-indole(CAS: 16066-91-4)

5-Iodo-1H-indole (CAS: 16066-91-4) is a crystalline compound with a molecular weight of approximately 247.02 g/mol. It has limited solubility in water but is more soluble in organic solvents like ethanol and acetone. This compound is relatively unreactive under normal conditions but can undergo nucleophilic substitution reactions, especially in the presence of strong bases or catalysts. Its stable crystalline form makes it suitable for various chemical applications.

5-Iodo-1H-indole (CAS: 16066-91-4) can be synthesized through the iodination of 1H-indole using reagents such as iodine and potassium iodide in the presence of a base like sodium hydroxide. The reaction is conducted in an organic solvent to enhance solubility and selectivity. This method provides a high yield of the target compound with good purity, making it a common approach in the laboratory and industry.

5-Iodo-1H-indole (CAS: 16066-91-4) is primarily used in the pharmaceutical industry for the synthesis of bioactive compounds and as an intermediate in medicinal chemistry. It also finds applications in the sensor technology sector, particularly in the development of colorimetric and fluorometric sensors. Additionally, it may be used in the research and development of new materials and polymers.

When handling 5-Iodo-1H-indole (CAS: 16066-91-4), it is essential to wear appropriate personal protective equipment (PPE), such as gloves, safety goggles, and lab coats. This compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of spills, they should be carefully cleaned up using absorbent materials, and the affected area should be flushed with water. Always refer to the safety data sheet (SDS) for specific handling instructions and emergency procedures.