1-(4-Chloro-2-pyridinyl)-1-propanone(CAS: 896139-36-9)

1-(4-Chloro-2-pyridinyl)-1-propanone (CAS: 896139-36-9) is a crystalline solid with a molecular weight of approximately 180.03 g/mol. It has a low solubility in water but is soluble in common organic solvents like ethanol and acetone. Chemically, it is highly reactive, particularly with nucleophiles, and is used in organic synthesis due to its electrophilic character. It is stable under normal storage conditions but should be protected from moisture and light.

1-(4-Chloro-2-pyridinyl)-1-propanone (CAS: 896139-36-9) is typically synthesized via an electrophilic aromatic substitution reaction using 4-chloropyridine and a protonating agent like triflic acid. The reaction is performed under mild conditions to achieve good yield and selectivity. Catalysts such as Lewis acids can enhance the reaction efficiency.

1-(4-Chloro-2-pyridinyl)-1-propanone (CAS: 896139-36-9) is primarily used in the pharmaceutical and fine chemical industries for the synthesis of various drug intermediates and APIs. It is also utilized in the polymer industry for functionalization purposes and in the development of sensors and semiconductors.

When handling 1-(4-Chloro-2-pyridinyl)-1-propanone (CAS: 896139-36-9), wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure the use of a fume hood to minimize inhalation risks. Store it in a dry, cool place away from direct sunlight. In case of spill, follow the safety data sheet (SDS) for disposal instructions and clean up carefully.