5-Iodopyrimidin-4-amine(CAS: 91416-96-5)

5-Iodopyrimidin-4-amine (CAS: 91416-96-5) is a crystalline solid with a molecular weight of approximately 241.01 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and dimethylformamide. The compound exhibits moderate reactivity, particularly towards nucleophiles, and is stable under normal storage conditions.

5-Iodopyrimidin-4-amine can be synthesized through a multi-step reaction involving the iodination of pyrimidine followed by amination. Commonly, pyrimidine is iodinated using sodium iodide and sodium hydroxide, and then aminating the product with an appropriate amine under basic conditions. This process requires careful control of pH and temperature to achieve good yield and selectivity.

5-Iodopyrimidin-4-amine (CAS: 91416-96-5) is primarily used in the pharmaceutical industry for the synthesis of drug intermediates. It also has applications in the development of sensors and semiconductors due to its unique chemical properties.

When handling 5-Iodopyrimidin-4-amine (CAS: 91416-96-5), wear appropriate personal protective equipment (PPE) including gloves and safety goggles. Work in a well-ventilated area or a fume hood to minimize inhalation risk. Follow standard laboratory safety protocols and keep the compound away from strong acids and bases. In case of spill, neutralize with an appropriate base and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling information.