How is 5-Iodopyrimidin-4-amine (CAS: 91416-96-5) typically synthesized?

5-Iodopyrimidin-4-amine can be synthesized through a multi-step reaction involving the iodination of pyrimidine followed by amination. Commonly, pyrimidine is iodinated using sodium iodide and sodium hydroxide, and then aminating the product with an appropriate amine under basic conditions. This process requires careful control of pH and temperature to achieve good yield and selectivity.