1-Aminocyclobutanecarboxylic acid(CAS: 22264-50-2)

1-Aminocyclobutanecarboxylic acid is a colorless crystalline solid with a molecular weight of approximately 113.12 g/mol. It has a pKa of about 6.4 and is slightly soluble in water. The compound exhibits moderate reactivity, particularly towards carbonyl compounds. It is used in various chemical reactions due to its amine and carboxylic acid functionalities.

1-Aminocyclobutanecarboxylic acid can be synthesized via the Mannich reaction, where cyclobutanone, formaldehyde, and an amine are reacted in the presence of an acid catalyst. The reaction provides good selectivity for the target compound with high yield. Other methods include direct amination of cyclobutanecarboxylic acid.

1-Aminocyclobutanecarboxylic acid is used in the pharmaceutical industry for the synthesis of certain drugs, in the polymer industry for the production of specific polymers, and in the chemical industry for various reactions. It is also used in the development of sensors and semiconductors due to its unique chemical properties.

When handling 1-Aminocyclobutanecarboxylic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place, and fume hoods should be used during handling to minimize inhalation risks. In case of spillage, follow the safety data sheet (SDS) guidelines for proper disposal and clean-up procedures.