5-Chloro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one(CAS: 180160-47-8)

5-Chloro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one (CAS: 180160-47-8) is a colorless to white crystalline solid with a molecular weight of approximately 272.7 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetonitrile. It exhibits moderate reactivity, particularly in the presence of nucleophiles and electrophiles. The compound is stable under normal conditions but should be stored away from moisture and heat.

5-Chloro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one (CAS: 180160-47-8) is synthesized via an electrophilic aromatic substitution reaction, where a piperidin ring is introduced onto a benzofuran ring. Commonly, it involves the use of an appropriate piperidin derivative and a chlorination step to introduce the chlorine substituent. The synthesis typically yields a high purity product with good selectivity and moderate to high yield.

5-Chloro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one (CAS: 180160-47-8) is primarily used in the pharmaceutical industry for the development of various medications, particularly in anticancer and anti-inflammatory drugs. It also has applications in the polymer industry for its potential use in the synthesis of functional polymers with specific properties. Additionally, it is explored for use in sensor technologies and semiconductor materials due to its unique structural features.

5-Chloro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one (CAS: 180160-47-8) should be handled in a well-ventilated area, preferably with a fume hood, due to its potential for inhalation hazards. Personal protective equipment (PPE) such as gloves, goggles, and a lab coat is essential to prevent skin contact and eye exposure. In the event of a spill, it should be handled according to the manufacturer's safety data sheet (SDS) guidelines. Storage should be in a cool, dry place away from direct sunlight and moisture.