(3beta,5alpha)-17-Oxoandrostan-3-yl acetate(CAS: 1239-31-2)

(3beta,5alpha)-17-Oxoandrostan-3-yl acetate is a white crystalline solid with a molecular weight of approximately 322.45 g/mol. It is poorly soluble in water but soluble in organic solvents such as ethanol and acetone. The compound exhibits moderate reactivity, particularly towards ester hydrolysis under basic conditions. It also shows some instability towards heat and light, which should be considered during storage and handling.

(3beta,5alpha)-17-Oxoandrostan-3-yl acetate is typically synthesized from androst-4-en-3-one via a series of reactions including reduction, oxidation, and acetylation. Commonly, the synthesis involves the use of sodium borohydride for reduction, acetic anhydride for acetylation, and catalytic hydrogenation for selectivity. The overall yield is generally around 70-80% depending on the reaction conditions and purity of starting materials.

(3beta,5alpha)-17-Oxoandrostan-3-yl acetate finds applications in the pharmaceutical industry as an intermediate in the synthesis of progestogens and other hormonal drugs. It is also used in the cosmetics industry for its potential anti-aging properties. Additionally, it may have applications in the agricultural sector as a growth regulator.

When handling (3beta,5alpha)-17-Oxoandrostan-3-yl acetate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbents. Follow standard safety protocols and consult the Material Safety Data Sheet (MSDS/SDS) for detailed instructions on handling, storage, and disposal.