6-Amino-N-methyl-2-naphthalenesulfonamide(CAS: 104295-55-8)

6-Amino-N-methyl-2-naphthalenesulfonamide is a crystalline solid with a molecular weight of approximately 262.23 g/mol. It has a solubility of about 7.5 mg/mL in water. The compound is moderately reactive, particularly under basic conditions. It is insoluble in common organic solvents such as dichloromethane and ethanol.

6-Amino-N-methyl-2-naphthalenesulfonamide can be synthesized via the sulfonation of 2-naphthol followed by amide coupling. The sulfonation step is catalyzed by concentrated sulfuric acid, and the coupling reaction involves the use of a suitable amine, often in the presence of a base like sodium hydroxide. The overall yield is generally around 75%.

6-Amino-N-methyl-2-naphthalenesulfonamide is primarily used in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients. It also finds applications in the polymer industry as a dye precursor, and in the sensor and semiconductor industries due to its electronic properties.

When handling 6-Amino-N-methyl-2-naphthalenesulfonamide, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately with water and proper waste handling procedures should be followed. Always refer to the safety data sheet (SDS) for detailed information on handling and storage.