2-Amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]benzonitrile(CAS: 675126-27-9)

2-Amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]benzonitrile is a crystalline solid with a molecular weight of approximately 376.41 g/mol. It is moderately soluble in common organic solvents like DMF and DMSO. The compound exhibits basic reactivity due to the amino group and is less reactive towards acidic conditions. It has a pKa around 8.5, indicating its basic nature.

2-Amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]benzonitrile is typically synthesized via a multistep process involving the reaction of 4-methoxy-5-hydroxybenzonitrile with morpholine followed by a propargylation reaction. The synthesis involves the use of a palladium catalyst and requires mild to moderate reaction conditions. The overall yield is around 70-75%.

2-Amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]benzonitrile is primarily used in the pharmaceutical industry for the synthesis of certain drug candidates. It is also explored for use in sensor technology and potentially in the polymer industry for its unique chemical properties.

Proper handling of 2-Amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]benzonitrile requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight. In the case of a spill, it is recommended to use a fume hood and follow standard laboratory safety protocols. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.