5-Chloro-1H-indole-3-carbaldehyde(CAS: 827-01-0)

5-Chloro-1H-indole-3-carbaldehyde (CAS: 827-01-0) is a crystalline compound with a molecular weight of approximately 181.61 g/mol. It has a high solubility in organic solvents like ethanol and acetone but is poorly soluble in water. Chemically, it is highly reactive, particularly with nucleophiles, and is often used as an intermediate in organic synthesis.

5-Chloro-1H-indole-3-carbaldehyde (CAS: 827-01-0) can be synthesized by the chlorination of indole-3-carbaldehyde using thionyl chloride in the presence of a base like pyridine. This reaction is typically carried out under anhydrous conditions to ensure high yield and selectivity.

5-Chloro-1H-indole-3-carbaldehyde (CAS: 827-01-0) is primarily used in pharmaceuticals and fine chemicals for the synthesis of various bioactive compounds. It is also used in the production of polymers and in the development of sensors and semiconductors due to its unique chemical properties.

When handling 5-Chloro-1H-indole-3-carbaldehyde (CAS: 827-01-0), it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be handled with great care and cleaned up using appropriate methods, and safety data sheets (SDS) should be consulted for detailed emergency procedures.