3-Amino-5-bromobenzonitrile(CAS: 49674-16-0)

3-Amino-5-bromobenzonitrile is a solid at room temperature with a crystalline form. Its molecular weight is approximately 240.01 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. The compound is reactive towards nucleophiles and can undergo substitution reactions. It is also prone to hydrolysis under basic conditions.

3-Amino-5-bromobenzonitrile can be synthesized by a multi-step process. First, bromination of benzonitrile is performed, followed by nitrile hydrolysis. Alternatively, it can be prepared from 5-bromobenzonitrile using an amino group introduction reaction. Commonly used reagents include bromine and potassium hydroxide, with yields ranging from 70-85%.

3-Amino-5-bromobenzonitrile is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry to produce functional materials with specific properties. Additionally, it has applications in the development of sensors and semiconductors due to its reactivity and chemical functionality.

When handling 3-Amino-5-bromobenzonitrile, safety glasses and gloves are essential to prevent skin contact and eye irritation. It should be handled in a well-ventilated area or fume hood to avoid inhalation. Spills should be cleaned up with caution using appropriate PPE. The safety data sheet (SDS) should always be consulted for detailed handling and emergency procedures. This compound can be toxic and should be stored in a cool, dry place away from strong oxidizers.