3-(trifluoromethyl)pyridin-2-amine(CAS: 183610-70-0)

3-(trifluoromethyl)pyridin-2-amine (CAS: 183610-70-0) is a white solid with a molecular weight of approximately 197.13 g/mol. It has a low solubility in water but is soluble in common organic solvents like DMF, DMSO, and THF. This compound is moderately reactive and can undergo electrophilic aromatic substitution reactions and nucleophilic substitution reactions.

3-(trifluoromethyl)pyridin-2-amine is typically synthesized via the amination of 3-(trifluoromethyl)pyridine with ammonia or an amine compound. The reaction is often performed in the presence of a suitable base like sodium hydride or potassium hydroxide, and a solvent such as dimethylformamide (DMF). Yields can range from 60% to 80%, depending on the reaction conditions and catalysts used.

3-(trifluoromethyl)pyridin-2-amine (CAS: 183610-70-0) is used in the pharmaceuticals industry for the development of organic compounds, particularly in the synthesis of new drug candidates. It is also utilized in the polymer industry for the modification of polymer properties, and in the chemical sensors sector for the design of sensitive detection systems.

When handling 3-(trifluoromethyl)pyridin-2-amine (CAS: 183610-70-0), it is important to use personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents, and the material should be handled according to the Safety Data Sheet (SDS).