6-Chloro-2-pyridinecarboxylic acid(CAS: 4684-94-0)

6-Chloro-2-pyridinecarboxylic acid is a crystalline solid with a molecular weight of approximately 162.02 g/mol. It is sparingly soluble in water and more soluble in organic solvents like ethanol and acetone. This compound is known for its acidic nature and is reactive with bases and nucleophiles. It decomposes above 250°C and is stable under normal laboratory conditions.

6-Chloro-2-pyridinecarboxylic acid can be synthesized via the reaction of 2-pyridinecarboxylic acid with thionyl chloride followed by hydrolysis. Other methods include direct chlorination of 2-pyridinecarboxylic acid with phosphorus oxychloride, which provides good yields and high purity. These methods ensure the compound is synthesized with high chemical selectivity and yield.

6-Chloro-2-pyridinecarboxylic acid is widely used in the pharmaceutical industry for the synthesis of intermediates in drug development. It also finds applications in the polymer industry for the production of advanced materials. Additionally, it is utilized in the electronics sector for the fabrication of semiconductors and sensors due to its unique chemical properties.

When handling 6-Chloro-2-pyridinecarboxylic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. This compound should be stored in a cool, dry place, away from incompatible materials like strong bases and oxidizers. Always use proper ventilation and work in a fume hood to minimize exposure. In case of a spill, neutralize the acid with a base and dispose of the material according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed emergency procedures.