(S)-Amlodipine | CAS No. 103129-82-4

(S)-Amlodipine

Basic Information

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CAS Number

103129-82-4

Molecular Formula

C20H25ClN2O5

Molecular Weight

408.88 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

102-104°C

SMILES

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CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN

InChI

InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3/t17-/m0/s1

InChIKey

HTIQEAQVCYTUBX-KRWDZBQOSA-N

LogP

2.2663

Topological Polar Surface Area

99.88000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 7

Complexity

647

Synonyms & References

English

Levamlodipine
CHEBI:53796
(S)-Amlodipine
MFCD09832686
HMS3885M19
S-Amlodipine
3-ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
CCG-268748
3-Ethyl 5-methyl (4S)-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
CS-0003533
3-O-ethyl 5-O-methyl (4S)-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
(-)-Amlodipine
BCP9000849
A800681
DTXSID50904504
levamlodipinum
Levoamlodipine Besylate
Levamlodipine [INN]
D97381
HTIQEAQVCYTUBX-KRWDZBQOSA-N
2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-3-ethoxy-carbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
levamlodipino
NS00098782
Q-101935
103129-82-4
LEVAMLODIPINE [WHO-DD]
s3674
AGSAV301 COMPONENT LEVAMLODIPINE
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-
Amlodipine, (s)-
UNII-0P6NLP6806

MDL Number

MFCD09832686

FAQ

What is (S)-Amlodipine (CAS: 103129-82-4)?

(S)-Amlodipine is a calcium channel blocker used in pharmaceuticals. Its chemical formula is C20H27NO5, and it exhibits solubility in ethanol and methanol. This enantiomer is known for its pharmacological activity in managing cardiovascular conditions, with a molecular weight of 345.43 g/mol. It is a key component in medications for hypertension and angina.

What are the main uses of (S)-Amlodipine (CAS: 103129-82-4)?

(S)-Amlodipine is primarily used as a pharmaceutical agent to treat hypertension, angina, and coronary artery disease. It is also employed in research for studying cardiovascular effects and in the development of drugs targeting peripheral vascular disorders. Its applications include improving blood flow and reducing arterial pressure.

Is (S)-Amlodipine (CAS: 103129-82-4) safe?

(S)-Amlodipine is considered safe when used as directed, with low toxicity in recommended doses. Safety guidelines emphasize avoiding direct contact with skin or eyes and following proper handling procedures. It complies with FDA and EPA standards, but precautions should be taken to prevent inhalation or ingestion during preparation or use.

How should (S)-Amlodipine (CAS: 103129-82-4) be stored?

(S)-Amlodipine should be stored in a cool, dry place at 20-25°C, away from light and moisture. It requires airtight containers to maintain stability and prevent degradation. Avoid exposure to heat and humidity, and ensure storage conditions align with pharmaceutical standards for optimal shelf life.