3-Amino-2-cyclohexen-1-one(CAS: 5220-49-5)

3-Amino-2-cyclohexen-1-one is a colorless liquid with a molecular weight of approximately 134.17 g/mol. It has a solubility of about 174 mg/L in water and is soluble in common organic solvents like ethanol and acetone. This compound is known for its reactivity, particularly in nucleophilic addition reactions and condensation reactions.

3-Amino-2-cyclohexen-1-one can be synthesized via the Wittig reaction using cyclohexenone and phenyltriphenylphosphonium bromide as a phosphonium salt. This method provides good yield and control over the reaction. Other methods involve the reduction of 3-keto-2-cyclohexenone with sodium borohydride or lithium aluminum hydride.

3-Amino-2-cyclohexen-1-one is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the production of aroma compounds and as a precursor in the polymer industry. Additionally, it is utilized in the development of certain sensors and as a reagent in analytical chemistry.

When handling 3-Amino-2-cyclohexen-1-one, it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure the area is well-ventilated and work in a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. Always consult the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) for detailed safety information.