3-Isopropoxyaniline(CAS: 41406-00-2)

3-Isopropoxyaniline is a white crystalline solid with a molecular weight of approximately 152.24 g/mol. It has a low solubility in water (0.3 g/100 mL at 20°C) but is more soluble in organic solvents like ethanol and acetone. Chemically, it is an amine and reacts readily with acids to form salts. It is also susceptible to oxidation and hydrolysis under certain conditions.

3-Isopropoxyaniline is commonly synthesized by the reaction of aniline with isopropyl alcohol in the presence of a strong acid, such as sulfuric acid. The reaction is believed to occur via a Williamson ether synthesis followed by an elimination step. The yield is typically around 75-85%, and the reaction is exothermic and requires careful temperature control.

3-Isopropoxyaniline is used in various industries, including pharmaceuticals, where it serves as a precursor for the synthesis of certain drugs. It is also utilized in the production of dyes and pigments, as well as in the manufacturing of coatings and adhesives. Additionally, it has applications in the polymer industry for the preparation of certain types of resins.

When handling 3-Isopropoxyaniline, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It is flammable and should be stored in a cool, well-ventilated area away from heat sources and oxidizers. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information.