(3S)-3-Amino-3-(2-methoxyphenyl)propanoic acid(CAS: 720662-28-2)

(3S)-3-Amino-3-(2-methoxyphenyl)propanoic acid is a colorless solid with a molecular weight of 228.32 g/mol. It has a pKa of approximately 2.5 and is soluble in water (200 mg/mL). This compound is moderately reactive, showing basicity due to its amino group and acidity due to the carboxylic acid group. It can form salts with bases and reacts with nucleophiles at the amino group.

(3S)-3-Amino-3-(2-methoxyphenyl)propanoic acid can be synthesized through the condensation of 2-methoxybenzaldehyde and methyl glycinate, followed by hydrogenation and hydrolysis. Commonly, a palladium catalyst is used for hydrogenation, and the reaction is typically carried out in an acidic environment to improve selectivity. The overall yield is around 70-80%.

(3S)-3-Amino-3-(2-methoxyphenyl)propanoic acid has applications in pharmaceuticals, where it serves as an intermediate in the synthesis of drugs. It is also used in the synthesis of certain polymers and as a component in some sensors due to its biochemical and functional properties.

When handling (3S)-3-Amino-3-(2-methoxyphenyl)propanoic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be handled in a fume hood due to potential inhalation hazards. Spills should be cleaned up with caution, using absorbent materials, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage recommendations.