4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine(CAS: 123148-78-7)

4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine is a crystalline solid with a molecular weight of approximately 343.02 g/mol. It has a low solubility in water but is more soluble in organic solvents like DMSO and DMF. The compound is moderately reactive, showing good stability under acidic and basic conditions but can degrade under strong oxidizing agents. It is a key intermediate in the synthesis of pharmaceuticals and other organic compounds.

4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine is typically synthesized via a multi-step process involving the iodination of 4-chloropyrimidine followed by pyrrole addition. Common catalysts include iodine and pyridine, and the reaction proceeds with high selectivity and good yield under appropriate conditions, usually in organic solvents.

4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine is used in the pharmaceutical industry as an intermediate for synthesizing antiviral drugs and other biologically active compounds. It is also used in polymer synthesis and as a component in sensors for detecting various chemical and biological agents.

Proper handling of 4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine requires the use of appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood. In case of spills, immediate cleanup should be performed using appropriate absorbent materials, and the area should be decontaminated. Refer to the safety data sheet (SDS) for specific instructions and emergency procedures.