5-Chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(2S)-1,1,1-trifluoro-2-propanyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine(CAS: 849550-05-6)

5-Chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(2S)-1,1,1-trifluoro-2-propanyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine is typically a crystalline solid with a molecular weight of approximately 567.6 g/mol. It has a low water solubility and moderate solubility in organic solvents. The compound is known for its specific reactivity, particularly with nucleophiles and electrophiles, and it is stable under normal conditions but may decompose under basic conditions.

This compound is synthesized via a multi-step process involving the protection of a primary amine, construction of the fluorophenyl moiety, and coupling reactions. Commonly, Suzuki and Sonogashira cross-coupling reactions are used with appropriate catalysts and reagents to achieve high selectivity and yield. The use of palladium catalysts is prevalent in such syntheses.

This compound is primarily used in the pharmaceutical industry, particularly in the development of antiviral and anticancer drugs. It may also find applications in the synthesis of novel materials for sensors and semiconductors due to its unique chemical properties.

Handling this compound requires the use of personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled carefully, using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for specific guidance. The substance is stable under normal conditions but should be stored in a cool, dry place away from strong acids and bases.