cis-3-Amino-1-methylcyclobutanol hydrochloride (1:1)(CAS: 1523571-03-0)

cis-3-Amino-1-methylcyclobutanol hydrochloride is a white crystalline solid with a molecular weight of approximately 178.72 g/mol. It has a pKa of about 1.7 and is highly soluble in water. This compound exhibits basic properties due to the presence of the amino group. It is reactive towards acid-base reactions and can participate in nucleophilic substitution reactions.

cis-3-Amino-1-methylcyclobutanol hydrochloride is typically synthesized via the reaction of 1-methylcyclobutanone with ammonia in the presence of a catalyst, such as sodium hydroxide. The process involves nucleophilic substitution, and yields about 60-70% of the desired product. Post-synthesis, hydrochloric acid is added to form the hydrochloride salt.

cis-3-Amino-1-methylcyclobutanol hydrochloride is used in the pharmaceutical industry for the synthesis of certain drugs due to its amino functionality. It is also used in the polymer industry for the modification of polymers to improve their physical properties. Additionally, it finds applications in the production of sensors and semiconductors.

When handling cis-3-Amino-1-methylcyclobutanol hydrochloride, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be handled in a fume hood to minimize exposure. Spills should be cleaned up using absorbent materials, and the area should be well-ventilated. Refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency response procedures.