(2R,5R)-5-Isopropenyl-2-methylcyclohexanone(CAS: 5524-05-0)

(2R,5R)-5-Isopropenyl-2-methylcyclohexanone (CAS: 5524-05-0) is a colorless to light yellow liquid with a molecular weight of approximately 154.24 g/mol. It has a high boiling point of around 207°C and a low solubility in water. The compound is moderately reactive, particularly with nucleophiles and bases. It can form crystalline forms under specific conditions, with melting points around -15°C to -10°C.

(2R,5R)-5-Isopropenyl-2-methylcyclohexanone (CAS: 5524-05-0) can be synthesized via a combination of methods, including Wittig olefination and subsequent reduction. Commonly, isopropyl vinyl ether reacts with tert-butyllithium to form an enolate, which then reacts with 2-methylcyclohexanone to produce the desired product. The overall yield is around 70-80%, and the method is known for its good selectivity.

(2R,5R)-5-Isopropenyl-2-methylcyclohexanone (CAS: 5524-05-0) finds applications in various industries. It is used in the synthesis of pharmaceuticals, particularly as a precursor to antifungal and antiviral drugs. In the polymer industry, it serves as a monomer for the production of certain types of polymers. Additionally, it is utilized in the development of sensors and in the electronics industry for the fabrication of semiconductors.

When handling (2R,5R)-5-Isopropenyl-2-methylcyclohexanone (CAS: 5524-05-0), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Operations should be conducted under a fume hood to minimize exposure. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.