Compound Q&A

How is (2R,5R)-5-Isopropenyl-2-methylcyclohexanone (CAS: 5524-05-0) typically synthesized?

Answer

(2R,5R)-5-Isopropenyl-2-methylcyclohexanone
(2R,5R)-5-Isopropenyl-2-methylcyclohexanone (CAS: 5524-05-0) can be synthesized via a combination of methods, including Wittig olefination and subsequent reduction. Commonly, isopropyl vinyl ether reacts with tert-butyllithium to form an enolate, which then reacts with 2-methylcyclohexanone to produce the desired product. The overall yield is around 70-80%, and the method is known for its good selectivity.

About

CAS No 5524-05-0
English Name (2R,5R)-5-Isopropenyl-2-methylcyclohexanone
Molecular Formula C10H16O
Molecular Weight 152.23699999999997 g/mol
SMILES C[C@@H]1CC[C@H](CC1=O)C(=C)C
InChIKey AZOCECCLWFDTAP-RKDXNWHRSA-N
Last Updated: 2025-10-10 21:10

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