3-Oxo-1,3-dihydro-2-benzofuran-1-yl 2-{[3-(trifluoromethyl)phenyl]amino}nicotinate(CAS: 66898-62-2)

3-Oxo-1,3-dihydro-2-benzofuran-1-yl 2-{[3-(trifluoromethyl)phenyl]amino}nicotinate is a crystalline solid with a molecular weight of approximately 497.38 g/mol. It is slightly soluble in common organic solvents like DMSO and methanol. The compound is reactive towards nucleophiles and can undergo various transformations. It exhibits good stability under neutral and basic conditions but is sensitive to strong acids.

3-Oxo-1,3-dihydro-2-benzofuran-1-yl 2-{[3-(trifluoromethyl)phenyl]amino}nicotinate is synthesized through a multi-step process involving the condensation of 3-(trifluoromethyl)aniline with 3-oxo-1,3-dihydro-2-benzofuran-1-carbaldehyde. The reaction typically requires the use of a catalyst like p-toluenesulfonic acid and is carried out in a polar aprotic solvent. The yield is usually around 70-80%.

3-Oxo-1,3-dihydro-2-benzofuran-1-yl 2-{[3-(trifluoromethyl)phenyl]amino}nicotinate is primarily used in the pharmaceutical and chemical industries. It serves as a precursor in the synthesis of various bioactive compounds and is also utilized in the development of new materials for sensors and semiconductors.

When handling 3-Oxo-1,3-dihydro-2-benzofuran-1-yl 2-{[3-(trifluoromethyl)phenyl]amino}nicotinate, ensure the use of appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Conduct reactions in a well-ventilated fume hood to minimize exposure. Spills should be handled with caution by using absorbent materials and rinsing the area with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.