1-(4-Bromophenyl)-1-propanone(CAS: 10342-83-3)

1-(4-Bromophenyl)-1-propanone is a colorless to yellowish liquid with a molecular weight of 236.01 g/mol. It is slightly soluble in water but miscible with common organic solvents such as ethanol, acetone, and toluene. Chemically, it is less reactive under normal conditions but can undergo nucleophilic substitution reactions. It has a high boiling point of 260°C and a melting point of -48°C.

1-(4-Bromophenyl)-1-propanone can be synthesized through a bromination reaction of acetophenone with bromine in the presence of a Lewis acid like aluminum bromide. The reaction is carried out under anhydrous conditions to minimize side reactions. The yield is typically around 70-80%, with high selectivity towards the desired product.

1-(4-Bromophenyl)-1-propanone is primarily used in the pharmaceutical and polymer industries. It serves as an intermediate in the synthesis of various drugs and also finds applications in the production of certain polymers. Its role in sensors and semiconductors is less common but still recognized in specific research areas.

Proper handling of 1-(4-Bromophenyl)-1-propanone requires wearing appropriate personal protective equipment (PPE), including gloves and safety goggles. It should be handled in a well-ventilated area or fume hood to avoid inhalation. In case of a spill, it should be cleaned up using appropriate absorbents, and the area should be flushed with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.