1-(2-Chlorophenyl)-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride (1:1)(CAS: 56776-01-3)

1-(2-Chlorophenyl)-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride is a white crystalline solid with a molecular weight of approximately 313.7 g/mol. It has a pKa of about 7.5 and is soluble in water and ethanol. This compound is characterized by its low reactivity under normal conditions but can undergo hydrolysis in basic conditions. It has a hydrochloride salt form, which enhances its stability and solubility.

1-(2-Chlorophenyl)-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride is typically synthesized by the reaction of 2-chloroaniline with 2-methyl-2-propanol followed by acetylation and hydrolysis. The reaction is performed in the presence of a suitable base and catalyst, and the product is isolated by recrystallization. The yield is around 75%, and the selectivity is good, with minimal side products.

1-(2-Chlorophenyl)-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride is used in the pharmaceutical industry as an intermediate for drug synthesis. It is also utilized in the polymer industry for the production of functional polymers and in the semiconductor industry for the fabrication of electronic components. Additionally, it finds applications in sensor technology due to its unique chemical properties.

When handling 1-(2-Chlorophenyl)-2-[(2-methyl-2-propanyl)amino]ethanol hydrochloride, ensure the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to minimize inhalation risk. Store the compound in a cool, dry place, away from direct sunlight and flammable materials. In case of spills, use appropriate absorbents and follow the safety data sheet (SDS) guidelines for disposal. Handle the compound with care to avoid skin contact and ingestion.