1-Allyl-1H-pyrrole-2,5-dione(CAS: 2973-17-3)

1-Allyl-1H-pyrrole-2,5-dione is a crystalline solid with a molecular weight of approximately 154.23 g/mol. It is slightly soluble in water but readily soluble in organic solvents such as ethanol and acetone. This compound is known for its reactivity towards nucleophiles and electrophiles, making it useful in various synthetic reactions. It has a melting point of around 83-85°C and is stable under normal conditions, but care should be taken in acidic or basic environments.

1-Allyl-1H-pyrrole-2,5-dione can be synthesized through a condensation reaction between pyrrole and allyl alcohol. Commonly, this involves the use of acid catalysts such as p-toluenesulfonic acid (p-TSA) or sulfuric acid. The reaction typically proceeds with good selectivity and moderate to high yield. The process is carried out under mild conditions, ensuring the formation of the desired product with minimal side reactions.

1-Allyl-1H-pyrrole-2,5-dione is primarily used in the pharmaceutical industry for the synthesis of various drug intermediates. It also finds applications in polymer science, where it is used as a monomer for the preparation of functional polymers. Additionally, it is utilized in the development of sensors and semiconductors due to its electronic properties and reactivity.

When handling 1-Allyl-1H-pyrrole-2,5-dione, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be cleaned up immediately using absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.