Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate(CAS: 152628-01-8)

Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate has a crystalline form with a molecular weight of approximately 312.33 g/mol. It is moderately soluble in common organic solvents like DMSO and ethanol. The compound is known for its reactivity, particularly towards nucleophilic aromatic substitution and ester hydrolysis.

Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate is synthesized through the amidation of methyl 3-methyl-5-nitrobenzoate with butyryl chloride in the presence of a base like triethylamine. The reaction typically yields a high percentage of the desired product with good selectivity.

Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate is used in the pharmaceutical industry for the synthesis of certain drug intermediates. It also finds applications in the polymer industry for the development of specialized polymers with specific properties.

When handling Methyl 4-(butyrylamino)-3-methyl-5-nitrobenzoate, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work in a fume hood to avoid exposure. In case of a spill, clean up with appropriate absorbent materials and dispose of according to laboratory safety protocols. Refer to the Safety Data Sheet (SDS) for detailed guidance.