2-(Pyridin-2-yl)cyclopropanecarboxylic acid(CAS: 90563-75-0)

2-(Pyridin-2-yl)cyclopropanecarboxylic acid is a solid with a crystalline form at room temperature. Its molecular weight is approximately 175.16 g/mol. The compound is slightly soluble in water but soluble in organic solvents like ethanol and acetone. It exhibits moderate reactivity, particularly in amide formation and nucleophilic substitution reactions.

2-(Pyridin-2-yl)cyclopropanecarboxylic acid can be synthesized via a multi-step reaction involving the coupling of cyclopropanecarboxylic acid chloride and 2-bromopyridine. This reaction is typically carried out in the presence of a base like triethylamine. The yield is around 80%, and the method ensures good selectivity and purity.

2-(Pyridin-2-yl)cyclopropanecarboxylic acid is utilized in the pharmaceutical industry for the synthesis of drugs that require specific functional groups. It is also used in the polymer industry for modifying polymer properties and in the sensor industry for its reactivity towards various analytes.

When handling 2-(Pyridin-2-yl)cyclopropanecarboxylic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbent materials, and the area should be rinsed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage instructions.