2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-4H-chromen-4-one(CAS: 855-97-0)

2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-4H-chromen-4-one (CAS: 855-97-0) is a crystalline compound with a molecular weight of approximately 348.24 g/mol. It is slightly soluble in water but more soluble in polar organic solvents like ethanol and acetone. The compound exhibits moderate reactivity, particularly in aromatic substitution reactions. It has a pKa around 4.5, indicating its basicity.

2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-4H-chromen-4-one (CAS: 855-97-0) can be synthesized via a multistep process involving the protection of phenol groups, followed by a Diels-Alder reaction. Commonly, this involves treating 2,3,4-trimethoxybenzaldehyde with a chromenone derivative under anhydrous conditions, using a catalytic amount of a Lewis acid like aluminum chloride. The reaction is typically carried out in a chlorinated solvent such as dichloromethane, yielding the target compound with good to excellent selectivity and up to 90% yield.

2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-4H-chromen-4-one (CAS: 855-97-0) finds applications in the pharmaceutical industry as a precursor for drug development, particularly in the synthesis of active pharmaceutical ingredients. It is also used in the polymer industry as a chromophore for colorants and dyes. Additionally, it has potential uses in sensor technology and semiconductor manufacturing, where its chromophoric properties are utilized.

When handling 2-(3,4-Dimethoxyphenyl)-5,7-dimethoxy-4H-chromen-4-one (CAS: 855-97-0), it is important to use appropriate personal protective equipment (PPE) including gloves, laboratory coat, and safety goggles. The compound should be handled in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.