5-{[5-(4-Fluorophenyl)-2-furyl]methylene}-1,3-thiazolidine-2,4-dione(CAS: 1218777-13-9)

5-{[5-(4-Fluorophenyl)-2-furyl]methylene}-1,3-thiazolidine-2,4-dione is a crystalline solid with a molecular weight of approximately 317.23 g/mol. It is slightly soluble in water and has poor solubility in most organic solvents. The compound is thermally stable and exhibits limited reactivity under normal conditions, although it may undergo hydrolysis in basic media. It is a colorless to white solid with a faint odor.

5-{[5-(4-Fluorophenyl)-2-furyl]methylene}-1,3-thiazolidine-2,4-dione is synthesized using a multi-step process involving the condensation of 5-(4-fluorophenyl)furan-2-one with thiosemicarbazide. The reaction typically requires mild heating and a suitable solvent. The yield can be improved by using a catalyst, and the product is purified by recrystallization from ethanol.

5-{[5-(4-Fluorophenyl)-2-furyl]methylene}-1,3-thiazolidine-2,4-dione is used in the pharmaceutical industry for its potential as an intermediate in the synthesis of medicinal compounds. It may also find applications in the polymer industry for its ability to enhance certain properties of polymers. Additionally, it can be utilized in the development of sensors and semiconductors due to its unique chemical structure.

When handling 5-{[5-(4-Fluorophenyl)-2-furyl]methylene}-1,3-thiazolidine-2,4-dione, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. Spills should be cleaned up immediately using appropriate absorbent materials, and proper disposal methods should be followed. Refer to the Material Safety Data Sheet (MSDS) for detailed safety information.