N-(3,4,5,6-Tetrahydro-2H-azepin-7-yl)glycine(CAS: 90152-88-8)

N-(3,4,5,6-Tetrahydro-2H-azepin-7-yl)glycine is a white crystalline solid with a molecular weight of approximately 228.25 g/mol. It has a solubility of about 50 mg/mL in water and poor solubility in common organic solvents like ethanol and acetone. This compound is relatively stable under normal conditions but may react with strong acids or bases. It has a pKa around 8.5, indicating a basic nature.

N-(3,4,5,6-Tetrahydro-2H-azepin-7-yl)glycine is typically synthesized via a multi-step reaction involving azepine synthesis followed by amidation. A common method involves the reaction of 2,3,4,5,6-pentahydroazepine with glycine, catalyzed by a suitable amide coupling agent. The overall yield is around 70-80%, with good selectivity to the desired product.

N-(3,4,5,6-Tetrahydro-2H-azepin-7-yl)glycine finds applications in various industries, particularly in pharmaceuticals and polymer chemistry. In pharmaceuticals, it serves as a precursor in the synthesis of certain drugs. In polymer chemistry, it is used as a monomer to prepare functionalized polymers with improved properties. It is also explored for use in sensors and semiconductor materials.

When handling N-(3,4,5,6-Tetrahydro-2H-azepin-7-yl)glycine, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Store it in a cool, dry place away from direct sunlight and strong acids or bases. Use a fume hood when performing synthesis or handling the compound to minimize exposure to fumes. Always refer to the safety data sheet (SDS) for detailed handling and disposal instructions.