2,6-Naphthyridin-1(2H)-one(CAS: 80935-77-9)

2,6-Naphthyridin-1(2H)-one (CAS: 80935-77-9) is a crystalline solid with a molecular weight of approximately 163.14 g/mol. It has a low solubility in water (0.1 g/100 mL at 25°C) and solubility in organic solvents like ethanol and acetone. Chemically, it is slightly acidic and can undergo nucleophilic substitution reactions. It is stable under normal conditions but should be stored away from strong bases and reducing agents.

2,6-Naphthyridin-1(2H)-one can be synthesized via the condensation of 2-amino-6-nitrobenzaldehyde with acetic anhydride, followed by reduction of the nitro group. Alternatively, it can be produced by the dehydration of 2,6-diamino-1,3,5-triazine under acidic conditions. These methods yield pure compounds with high selectivity and good to excellent yields.

2,6-Naphthyridin-1(2H)-one (CAS: 80935-77-9) finds applications in the pharmaceutical industry as a precursor for drug synthesis, in the polymer industry for the development of novel materials, and in the sensor industry for the fabrication of gas-sensitive materials. It is also used in the semiconductor industry as a dopant material.

When handling 2,6-Naphthyridin-1(2H)-one (CAS: 80935-77-9), wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work in a fume hood to minimize inhalation risk. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.