2-Aminoisophthalonitrile(CAS: 63069-52-3)

2-Aminoisophthalonitrile has a crystalline form with a molecular weight of approximately 169.08 g/mol. It is slightly soluble in water but more soluble in organic solvents like acetonitrile. The compound is reactive and can undergo nucleophilic substitution reactions. It is a white or off-white solid with a melting point of about 140-142°C.

2-Aminoisophthalonitrile is typically synthesized via the amination of isophthalonitrile using an appropriate amine and a suitable catalyst. Commonly, this involves the reaction of isophthalonitrile with ammonia in the presence of a strong acid catalyst such as hydrochloric acid, yielding a 90% to 95% yield.

2-Aminoisophthalonitrile finds applications in various industries. It is used in the pharmaceutical industry for the synthesis of certain drugs, in the polymer industry as a monomer, and in the electronics industry for the production of sensors and semiconductors. Its versatility makes it a valuable intermediate in these sectors.

When handling 2-Aminoisophthalonitrile, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up with appropriate absorbent material, and the area should be ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.