2-Amino-5-pyrimidinecarboxylic acid(CAS: 3167-50-8)

2-Amino-5-pyrimidinecarboxylic acid is a white crystalline solid with a molecular weight of approximately 145.14 g/mol. It is slightly soluble in water and has a pKa of 4.7. The compound is known for its reactivity, particularly in nucleophilic substitution reactions and condensation reactions.

2-Amino-5-pyrimidinecarboxylic acid is typically synthesized via the condensation of 5-Amino-2-carboxypyrimidine with amines. Commonly used catalysts include strong acids such as trifluoroacetic acid. The reaction is carried out under anhydrous conditions to ensure high yield and selectivity.

2-Amino-5-pyrimidinecarboxylic acid is primarily used in the pharmaceutical industry as an intermediate for the synthesis of drugs. It also finds applications in the polymer industry for the development of functional materials, and in the electronics sector for the fabrication of semiconductor materials and sensors.

When handling 2-Amino-5-pyrimidinecarboxylic acid, it is important to use personal protective equipment (PPE) including gloves, safety glasses, and a lab coat. The compound should be stored in a dry, cool place, away from incompatible materials. In case of a spill, it should be cleaned up using appropriate absorbent materials, and the area should be well ventilated. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal.