Methyl 2-chloro-6-methylpyrimidine-4-carboxylate(CAS: 89793-11-3)

Methyl 2-chloro-6-methylpyrimidine-4-carboxylate (CAS: 89793-11-3) is a crystalline compound with a molecular weight of approximately 221.6 g/mol. It is sparingly soluble in water but highly soluble in organic solvents like methanol and ethanol. Chemically, it is moderately reactive, exhibiting electrophilic substitution at the chloro and methyl groups. It is stable under normal conditions but should be stored in a dry, shaded area to avoid hydrolysis.

Methyl 2-chloro-6-methylpyrimidine-4-carboxylate (CAS: 89793-11-3) is typically synthesized via the condensation of methyl 4-carboxy-2-chloropyrimidine-6-carbaldehyde with 2-methylbenzene-1,4-diol in the presence of a base like sodium hydroxide. The reaction is carried out in an aprotic solvent such as dimethylformamide (DMF) under mild conditions, providing a yield of about 75%. The reaction is selective and produces the desired product with high purity.

Methyl 2-chloro-6-methylpyrimidine-4-carboxylate (CAS: 89793-11-3) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also has applications in the polymer industry for the development of novel materials, and in the semiconductor industry for the production of organic semiconductors. Additionally, it can be used in sensor technology for its unique chemical properties.

When handling Methyl 2-chloro-6-methylpyrimidine-4-carboxylate (CAS: 89793-11-3), ensure the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Avoid contact with skin and eyes. Spills should be cleaned up immediately using appropriate absorbents, and the area should be ventilated thoroughly. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.