4-iodo-1-(4-methoxybenzyl)-1H-pyrazole(CAS: 905751-58-8)

4-Iodo-1-(4-methoxybenzyl)-1H-pyrazole (CAS: 905751-58-8) is a crystalline solid with a molecular weight of approximately 329.14 g/mol. It is slightly soluble in water but soluble in common organic solvents like ethanol and acetonitrile. The compound exhibits moderate reactivity towards nucleophiles, making it useful in various chemical transformations. It has a melting point of around 160-165°C and is stable under normal laboratory conditions.

4-Iodo-1-(4-methoxybenzyl)-1H-pyrazole is typically synthesized via a multistep process involving the reaction of 4-methoxybenzylamine with 4-bromo-1H-pyrazole in the presence of a base like potassium carbonate, followed by iodination using iodine in the presence of a Lewis acid such as aluminum chloride. The reaction yields the target compound with good selectivity and moderate to high yields depending on the specific conditions.

4-Iodo-1-(4-methoxybenzyl)-1H-pyrazole (CAS: 905751-58-8) finds applications in the pharmaceutical industry where it serves as a precursor for drug synthesis. It is also used in the polymer industry for developing specialized materials. Additionally, it has potential roles in the synthesis of sensors and semiconductors due to its unique electronic properties.

When handling 4-iodo-1-(4-methoxybenzyl)-1H-pyrazole (CAS: 905751-58-8), it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and flammable materials. Fume hoods should be used during the handling and synthesis of this compound. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and guidelines.