4-Chloropyridazine(CAS: 17180-92-6)

4-Chloropyridazine is a crystalline solid with a molecular weight of 142.54 g/mol. It has a melting point of 158-159°C and is slightly soluble in water. It is reactive towards bases and exhibits moderate reactivity with nucleophiles. The compound is used in organic synthesis and as a starting material for the production of other compounds.

4-Chloropyridazine can be synthesized from pyridine chlorination. The chlorination is typically carried out using thionyl chloride as the reagent. The reaction is performed under anhydrous conditions to increase the yield and selectivity of the product. The process involves heating the mixture to a temperature of around 100°C and then purifying the product through recrystallization or distillation.

4-Chloropyridazine is used in the pharmaceutical industry as an intermediate for the synthesis of drugs. It is also used in the production of herbicides and dyes. Additionally, it can be utilized in the synthesis of other organic materials, such as polymers and sensors, due to its functional groups.

Proper safety measures should be taken when handling 4-Chloropyridazine. It is recommended to wear personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a cool, dry place away from heat and ignition sources. In case of spill, it should be handled in a fume hood using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.