5-Hydroxynicotinonitrile(CAS: 152803-24-2)

5-Hydroxynicotinonitrile (CAS: 152803-24-2) is a white crystalline solid with a molecular weight of approximately 145.12 g/mol. It is slightly soluble in water but more soluble in organic solvents such as ethanol and acetone. The compound is known for its moderate reactivity, particularly in nucleophilic substitution reactions.

5-Hydroxynicotinonitrile is typically synthesized via the hydroxylammonium nitrite method. A common procedure involves the reaction of hydroxylamine hydrochloride with nicotinonitrile in the presence of a catalyst such as sodium hydroxide. The yield can be up to 85%, and the method is known for its high selectivity.

5-Hydroxynicotinonitrile (CAS: 152803-24-2) is used in various industries, including pharmaceuticals for intermediate production, sensors for detecting specific chemical species, and in the synthesis of certain polymers. Its applications are expanding due to its unique chemical properties.

When handling 5-Hydroxynicotinonitrile (CAS: 152803-24-2), it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be handled with caution, and appropriate spill cleanup procedures should be followed. Always refer to the Safety Data Sheet (SDS) for detailed instructions.