Androst-4-ene-3,11,17-trione(CAS: 382-45-6)

Androst-4-ene-3,11,17-trione (CAS: 382-45-6) is a steroidal compound. It is a white crystalline solid with a molecular weight of approximately 280.43 g/mol. The compound is sparingly soluble in water and more soluble in organic solvents like ethanol and acetone. It is relatively stable but can undergo hydrolysis under basic conditions. It is not highly reactive but can participate in hydrogenation reactions under mild conditions.

Androst-4-ene-3,11,17-trione can be synthesized via various routes. One common method involves the reduction of androst-4-en-3-one to androst-4-ene, followed by a Claisen condensation with acetone to form the trione. The synthesis typically uses sodium borohydride for the reduction step and an appropriate base like sodium hydroxide for the condensation. The yield and selectivity are influenced by the conditions used.

Androst-4-ene-3,11,17-trione is primarily used in the pharmaceutical industry for the production of steroid hormones and progestogens. It is also utilized in research applications, particularly in the development of new drugs and biochemical studies. Additionally, it can be employed in the polymer industry for synthesizing certain polymers and in the sensor and semiconductor industries for specialized applications.

When handling Androst-4-ene-3,11,17-trione (CAS: 382-45-6), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or under a fume hood to minimize inhalation risks. In case of a spill, it should be cleaned up immediately using appropriate absorbents and disposing of the waste according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed guidelines.