Ethyl 1-methyl-1H-pyrrole-3-carboxylate(CAS: 68384-82-7)

Ethyl 1-methyl-1H-pyrrole-3-carboxylate is a colorless liquid with a molecular weight of approximately 160.22 g/mol. It is poorly soluble in water but miscible with most organic solvents. The compound is moderately reactive, particularly with strong bases and nucleophiles. It can be stored in a cool, dark place away from heat sources.

Ethyl 1-methyl-1H-pyrrole-3-carboxylate can be synthesized via the reaction of ethyl acetoacetate with ethyl isocyanide in the presence of a Lewis acid catalyst such as aluminum chloride. The reaction yields the product with good selectivity and high yield.

Ethyl 1-methyl-1H-pyrrole-3-carboxylate is used in the pharmaceutical industry for the synthesis of certain APIs and in the chemical industry for the production of various organic compounds. It also finds applications in the polymer industry for modifying polymer properties.

When handling Ethyl 1-methyl-1H-pyrrole-3-carboxylate, appropriate personal protective equipment (PPE) should be worn, including gloves, safety glasses, and a lab coat. The compound should be handled in a well-ventilated area or fume hood to minimize inhalation risk. Spills should be cleaned up carefully, and the material safety data sheet (MSDS) should be consulted for detailed instructions.