1-(2-Bromo-4-fluorophenyl)methanamine hydrochloride (1:1)(CAS: 289038-14-8)

1-(2-Bromo-4-fluorophenyl)methanamine hydrochloride is a crystalline compound with a molecular weight of approximately 313.13 g/mol. It has a pKa of about 1.9 and is highly soluble in water and ethanol. The compound is moderately reactive, especially under acidic conditions. It exhibits good solubility in common organic solvents such as dichloromethane and acetonitrile but is less soluble in polar aprotic solvents like dimethylformamide.

1-(2-Bromo-4-fluorophenyl)methanamine hydrochloride is commonly synthesized by the reaction of 2-bromo-4-fluorophenylamine with hydrochloric acid. This process involves the bromination of a phenol followed by the amine reaction, resulting in the formation of the hydrochloride salt. The reaction is typically carried out in a solvent such as methanol or ethanol under reflux conditions. The yield is usually around 75-85%, with high selectivity towards the desired product.

1-(2-Bromo-4-fluorophenyl)methanamine hydrochloride finds applications in the pharmaceutical and polymer industries. It is used as a precursor in the synthesis of pharmaceutical compounds and as a monomer in the production of advanced polymers. Additionally, it is explored in the development of sensors and semiconductors due to its unique chemical properties.

When handling 1-(2-Bromo-4-fluorophenyl)methanamine hydrochloride, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. This compound should be used in a well-ventilated area or under a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. In case of skin contact or inhalation, seek medical attention. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.