2-Fluoro-4-formylbenzoic acid(CAS: 604000-97-7)

2-Fluoro-4-formylbenzoic acid is a crystalline solid with a molecular weight of approximately 183.05 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetonitrile. The compound is reactive towards nucleophiles and can undergo condensation reactions. It has a pKa of about 4.4, indicating moderate acidity.

2-Fluoro-4-formylbenzoic acid is typically synthesized from 4-formylbenzoic acid via a halogenation reaction using fluorine gas or a fluorinating agent like sulfur hexafluoride. The reaction is catalyzed by a suitable base and is carried out under anhydrous conditions to ensure high yield and selectivity.

2-Fluoro-4-formylbenzoic acid is used in the pharmaceutical industry for the synthesis of certain drug precursors and intermediates. It also finds applications in the polymer industry, where it is used as a monomer in the production of functional polymers. Additionally, it is employed in the development of sensors and semiconductors for its specific chemical properties.

When handling 2-Fluoro-4-formylbenzoic acid, it is important to wear protective equipment such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and heat sources. Operations should be conducted in a well-ventilated area or fume hood. Spills should be handled with caution and cleaned up using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.