2-[(2-Hydroxybenzylidene)amino]phenol(CAS: 1761-56-4)

2-[(2-Hydroxybenzylidene)amino]phenol is a white to off-white crystalline solid with a molecular weight of approximately 222.21 g/mol. It has a moderate solubility in water (2.5 g/L at 25°C) and poor solubility in common organic solvents. The compound is moderately reactive towards bases and reducing agents. It is stable under normal storage conditions but should be protected from strong acids and oxidizing agents.

2-[(2-Hydroxybenzylidene)amino]phenol can be synthesized via a condensation reaction between 2-hydroxybenzaldehyde and phenylhydrazine. This process is catalyzed by a strong base like sodium hydroxide and typically yields the product in good to high yield. The reaction is performed in a solvent such as ethanol, and the intermediate is purified by recrystallization.

2-[(2-Hydroxybenzylidene)amino]phenol is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It also has applications in the polymer industry for preparing functionalized polymers, and in the development of sensors and semiconductors due to its photoreactivity.

When handling 2-[(2-Hydroxybenzylidene)amino]phenol, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation of vapors. In case of a spill, the area should be decontaminated using appropriate cleaning agents, and the material safety data sheet (MSDS) should be consulted for specific spill procedures. Storage should be in a cool, dry place away from strong acids and oxidizing agents.