5-Cyanopyrazine-2-carboxylic acid(CAS: 1211533-09-3)

5-Cyanopyrazine-2-carboxylic acid is a white crystalline solid with a molecular weight of 198.14 g/mol. It has a melting point of 236-238°C and is slightly soluble in water. This compound is reactive towards nucleophiles and can undergo amide formation and cyanation reactions.

5-Cyanopyrazine-2-carboxylic acid can be synthesized via direct cyanation of 5-pyrazinecarboxylic acid using sodium cyanide in the presence of a base like sodium hydroxide. The yield is typically around 85-90%, with good selectivity for the target product.

5-Cyanopyrazine-2-carboxylic acid finds applications in the pharmaceutical industry, particularly in the synthesis of drugs targeting inflammation and pain. It is also used in the polymer industry for the development of new materials with improved properties.

When handling 5-Cyanopyrazine-2-carboxylic acid, wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work in a well-ventilated fume hood to avoid inhalation. Ensure proper storage in a cool, dry place away from heat sources and incompatible materials. Always refer to the Safety Data Sheet (SDS) for specific safety guidelines.