Purmorphamine(CAS: 483367-10-8)

Purmorphamine is a small molecule compound with a crystalline form. Its molecular weight is approximately 299.32 g/mol. Purmorphamine is slightly soluble in water but highly soluble in organic solvents such as DMSO and DMF. It is relatively stable in air and under standard laboratory conditions. Reactivity is moderate, with potential for hydrolysis under basic conditions.

Purmorphamine is synthesized through a multi-step process involving the condensation of 2-aminobenzoxazole and 2,3-dihydro-1H-inden-1-one. Commonly used catalysts include palladium(II) acetate and triphenylphosphine. The overall yield is moderate, and the method provides good selectivity for the desired product.

Purmorphamine is primarily used in the pharmaceutical industry for its role as a small molecule activator of the Hedgehog pathway. It is also utilized in the polymer industry for its potential to enhance material properties. Additionally, it is explored in the field of semiconductors for its electronic and optical properties.

Purmorphamine should be handled with personal protective equipment (PPE) including gloves and safety goggles. It is advisable to conduct experiments in a well-ventilated area or fume hood to minimize exposure. Spills should be cleaned up using appropriate disposal methods as outlined in the Safety Data Sheet (SDS). Storage should be in a cool, dark place away from incompatible materials.