Vonoprazan(CAS: 881681-00-1)

Vonoprazan is a white to off-white powder with a molecular weight of approximately 414.47 g/mol. It has a pKa of about 13.5, indicating poor aqueous solubility. The compound is slightly soluble in water and more soluble in organic solvents like methanol and ethanol. Vonoprazan is stable under normal temperature and pressure conditions but should be protected from moisture to prevent degradation.

Vonoprazan is synthesized via a multi-step process that involves acylation, alkylation, and condensation reactions. Key steps include the introduction of a trifluoromethyl group and an imidazole ring. The synthesis typically uses catalysts like sulfuric acid and employs high selectivity and yield, with the final product purified by recrystallization and chromatography.

Vonoprazan is primarily used in the pharmaceutical industry. It is an inhibitor of gastric proton pumps and is marketed as a medication for the treatment of gastroesophageal reflux disease (GERD) and peptic ulcer disease. There are no significant applications in other industries such as polymers, sensors, or semiconductors.

When handling Vonoprazan, appropriate Personal Protective Equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Storage should be in a tightly sealed container in a cool, dry place away from moisture and heat. Any spills should be handled with care, using appropriate spill kits, and the area should be well-ventilated. Safety Data Sheets (SDS) should be consulted for detailed handling and safety information.