Compound Q&A

How is Vonoprazan (CAS: 881681-00-1) typically synthesized?

Answer

Vonoprazan
Vonoprazan is synthesized via a multi-step process that involves acylation, alkylation, and condensation reactions. Key steps include the introduction of a trifluoromethyl group and an imidazole ring. The synthesis typically uses catalysts like sulfuric acid and employs high selectivity and yield, with the final product purified by recrystallization and chromatography.

About

English Name Vonoprazan
Molecular Formula C17H16FN3O2S
Molecular Weight 345.4 g/mol
SMILES CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CN=CC=C3
InChIKey BFDBKMOZYNOTPK-UHFFFAOYSA-N
Last Updated: 2025-09-07 10:19

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